Publications
168
Citations h-index
23,500+ 56
Patents & Commercialization
11
Selected Publications
(160+ publications with >23,000 total citations)
See the full list of publications at Google Scholar or PubMed
Research Articles (selected from 100+ papers)
Reviews and Books (out of 60+ papers)
Repurposing salicylic acid as a versatile inducer of proximity
Nature Chemical Biology 2025. Accepted
RNA-mediated condensation of TFE3 oncofusions facilitates transcriptional hub formation to promote translocation renal cell carcinoma (tRCC)
Nature Communications 2025 (in revision)
Engineering of photo-inducible binary interaction tools for biomedical applications
Nature Communications 2025 (in revision)
Perturbation of TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth.
Nature Cell Biology 2024. Online
TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells.
Nature Aging 2023. Online (News & Views)
Engineering of NEMO as calcium indicators with large dynamics and high sensitivity.
Nature Methods 2023. Tools available here
Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy.Nature Communications 2023. Open access
Light activated macromolecular phase separation modulates transcription by reconfiguring chromatin interactions.
Science Advances 2023. Open access
The Disordered N-terminal Domain of DNMT3A is Required for Postnatal Development. Nature Genetics 2022.
Identification of a STIM1 splicing variant that promotes glioblastoma growth.
Advanced Science. 2022 (cover story)
Optical control of protein delivery and partitioning in the nucleolus.
Nucleic Acids Research. 2022. Open access
Nano-optogenetic engineering of CAR T-cells for precision immunotherapy with enhanced safety. Nature Nanotechnology 2021 Open access
Circularly permuted LOV2 as a modular domain for optogenetic engineering. Nature Chemical Biology 2021. Open access
Engineering of a bona fide light-operated calcium channel. Nature Communications 2021. Open access (Technology licensed)
Expression of chimeric antigen receptor therapy targets detected by single-cell sequencing of normal cells contributes to off-tumor toxicity.
Cancer Cell 2021
Optogenetic control of non-apoptotic cell death.
Advanced Science 2021 (cover story) Open access
Caffeine-operated synthetic modules for chemogenetic control of protein activities by life style.
Advanced Science 2021 (cover story). Open access (Technology licensed)
Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling. Nature Communications 2020. Open access
Calcium sensing by the STIM1 ER-luminal domain.
Nature Communications 2018
Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks.
Nature Communications 2018
Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein. Nature Communications 2017
The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors.
Nature Cell Biology 2017
Optogenetic Control of Voltage-Gated Calcium Channels.
Angewandte Chemie Internatonal Edition Engl. 2018 (cover article)
Engineered Split-TET2 Enzyme for Inducible Epigenetic Remodeling.
JACS 2017. Open access. (JACS Spoltlight article)
Optical control of membrane tethering and interorganellar communication at nanoscales.
Chemical Science. 2017 (cover story)
Mutations in 5-methylcytosine oxidase TET2 and RHOA cooperatively disrupt T cell homeostasis.
Journal of Clinical Investigation. 2017
The LINK-A lncRNA activates normoixc HIF1α signaling in triple-negative breast cancer.
Nature Cell Biology 2016
Proteomic mapping of ER-PM junctions identifies STIMATE as a novel regulator of calcium influx. Nature Cell Biology 2015. Open access (highlighted N&V)
Inside-out calcium signaling prompted by STIM1 conformational swtich.
Nature Communications 2015. Open access
Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation.
eLife 2015. Open access
STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel.
Nature Communications 2014.
Initial activation of STIM1, the regulator of store-operated calcium entry.
Nature Structural & Molecular Biology 2013. Open access
STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nature Structural & Molecular Biology 2010. Open access
Pore architecture of the ORAI1 store-operated calcium channel.
PNAS 2010. Open access
Interrogating physiological functions with light and chemicals. Annual Review of Physiology 2025 (under review)
Optogenetic engineering for precision immunotherapy.
Trends in Pharmacological Sciences 2025 (accepted)
Optogenetic engineering of ion channels with tailored function.
Current Opinion in Chemical Biology 2025. Access here
Remote control of cellular immunotherapy. Nature Reviews Bioengineering 2023. Open access
A PASS for protein secretion.Nature Chemical Biology 2023. Open access
Optophysiology: illuminating cell physiology with optogenetics. Physiological Reviews 2022 (cover article). Access here
Optogenetics for transcriptional programming and genetic engineering. Trends in Genetics 2022 (cover article). Access here
Targeting epigenetic regulatory machinery to overcome cancer therapy resistance. Seminars in Cancer Biology 2022 (cover article). Access here
Opsin-free optogenetics: technology and applications
Book Co-Editor; CRC Press. 2022. Amazon link
Intelligent cell-based therapies for cancer and autoimmune disorders. Current Opinion in Biotechnology 2020. Access here
Optogenetic approaches to control calcium-modulated physiological processes. Current Opinion in Physiology 2020. Free access
Optogenetic immunomodulation: shedding light to anti-tumor immunity. Trends in Biotechnology 2017. Open access
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