2025 publications (17)
Repurposing salicylic acid as a versatile inducer of proximity.
Wang T, Liu S, Ke Y, Ali S, Wang R, Hong T, Liu Z, Ma G, Wang F, Zhu X, Huang Y, and Zhou Y#.
Nature Chemical Biology 2025,21(9):1444-56.
*Featured in Nature Chemical Biology News & Views: “A SAMBA for chemically induced proximity”. *Highlighted by Vital Record: "New research repurposes ancient remedy for blood cancer treatment". Highlighted by Futurity: “Common pain med ingredient could treat blood cancers”
Glycosphingolipids Regulate Phosphatidylserine Transport Machinery that Operates at ER-PM contact sites. Gannaban R, Ali S, Chen W, Nguyen M, Moore T, Zhou Y#, Hancock J#, Liu J#. Nature Communications 2025 (in revision)
RNA-mediated condensation of TFE3 oncofusions facilitates transcriptional hub formation to promote translocation renal cell carcinoma.
Guo L, Zhao R, Lee YT, Huang J, Wengler J, Rivera L, Hong T, Wang T, Rathod K, Suris A, Cai X, Wang R, Zhou Y#, and Huang Y#.
Nature Communications 2025,16(1):8712.
*Highlighted by Vital Record: "Disrupting cancer’s secret hubs: A new way to halt tumor growth". Highlighted by the The Academic Minute, Northeast Public Radio; Technology Networks:”RNA hijacking revealed as engine of childhood kidney cancer”; ScienMag: “Uncovering tumor’s hidden networks: a novel strategy to stop cancer growth”; The Medical News: “Researchers engineer a tool to dismantle cancer’s RNA-built growth hubs”.
Engineering of photo-inducible binary interaction tools for biomedical applications. Lee YT, Guo L, Lan TH, Nonomura T, Liu G, Ma G, Wang R, Huang Y, and Zhou Y#. Nature Communications 2025,16(1):6940. *Highlighted by Vital Record: "Compact genetic light switches transform disease control". Featured by MIRAGE: “Genetic Light Switches Revolutionize Disease Control”; Technology Networks: “Scientists Create Light-Activated Genetic Tools”; Bioengineer.org and ScienMag: “Tiny Genetic Light Switches Revolutionize Disease Control”; AZO Life Sciences: “PhoBITs Enable Unprecedented Control of Cellular Pathways with Blue Light”. Reprogramming chemically induced dimerization systems with nanobody scaffolds. Wang T, Nonomura T, Cui M, Lan TH, Cai PX, He L, and Zhou Y. Chemical Science 2025. Featured as a Cover Article. Access here. A single-component optogenetic toolkit for programmable control of microtubule. Ma G, Liu X, Lan TH, Duong T, Chiu M, Du D, Reiner DJ, Huang Y#, Ma G#, and Zhou Y#. Biorxiv 2025. Access here. Developing CRAC channel-based optogenetics to study calcium signaling processes. Nonomura T, Liu X, Chiu M, Tan Z, Lan Tien-Hung, and Zhou Y. Cold Spring Harbor Perspectives in Biology. 2025:a041760. Access here. Interrogating physiological functions with light and chemicals.Wang T, Zhang K, and Zhou Y#.Annual Review of Physiology. 2025. Access here Ternary-code DNA methylation dynamics: a new era for scalable mapping. Zhou Y, Huang Y. Cell Genomics 2025,5(9):101006.
A chemogenetic toolkit for inducible cell type-specific actin disassembly. Lan TH, Ambiel N, Zhou Y#, and Zuchero JB#. Small Methods. 2025,e2401522. Features as a Front-piece Cover Article. Optogenetic engineering for precision immunotherapy. Ke Y, Liu S, Huang Y, and Zhou Y#. Trends in Pharmacological Sciences. 2025,46(10):1018-37. (highlighted as a Cover Article)
Optogenetic engineering for ion channel modulation. Wang T, Nonomura T, Lan TH, and Zhou Y #. Current Opinion in Chemical Biology. 2025,85:102569. Heterochromatin deregulation during hematopoietic stem progenitor cell aging. Hong T, Guo L, Guzman A, You J, Goodell M, Zhou Y, and Huang Y. Cancer Research 85: IA011-IA011. Harnessing viral proteases for cellular and molecular engineering. Cui M, Tien-Hung Lan, and Zhou Y#. Chemistry-Methods. 2025,e202400098.
Optogenetic control of T cells for immunomodulation. McKee B, Liu S, Lan TH, and Zhou Y#. Essays in Biochemistry. 2025, EBC20253014. Modulation of ion channels with nanobodies.Sher A, Suris A, Huang Y, and Zhou Y#. Synthetic and Systems Biotechnology. 2025,10(2):593-9.
STIM1 and lipid interactions at ER-PM contact sites. Ke Y, Gannaban R, Liu J, and Zhou Y#. American Journal of Physiology – Cell Physiology. 2025,328(1):C107-C114.
Engineering of photo-inducible binary interaction tools for biomedical applications. Lee YT, Guo L, Lan TH, Nonomura T, Liu G, Ma G, Wang R, Huang Y, and Zhou Y#. Nature Communications 2025,16(1):6940. *Highlighted by Vital Record: "Compact genetic light switches transform disease control". Featured by MIRAGE: “Genetic Light Switches Revolutionize Disease Control”; Technology Networks: “Scientists Create Light-Activated Genetic Tools”; Bioengineer.org and ScienMag: “Tiny Genetic Light Switches Revolutionize Disease Control”; AZO Life Sciences: “PhoBITs Enable Unprecedented Control of Cellular Pathways with Blue Light”. Reprogramming chemically induced dimerization systems with nanobody scaffolds. Wang T, Nonomura T, Cui M, Lan TH, Cai PX, He L, and Zhou Y. Chemical Science 2025. Featured as a Cover Article. Access here. A single-component optogenetic toolkit for programmable control of microtubule. Ma G, Liu X, Lan TH, Duong T, Chiu M, Du D, Reiner DJ, Huang Y#, Ma G#, and Zhou Y#. Biorxiv 2025. Access here. Developing CRAC channel-based optogenetics to study calcium signaling processes. Nonomura T, Liu X, Chiu M, Tan Z, Lan Tien-Hung, and Zhou Y. Cold Spring Harbor Perspectives in Biology. 2025:a041760. Access here. Interrogating physiological functions with light and chemicals.Wang T, Zhang K, and Zhou Y#.Annual Review of Physiology. 2025. Access here Ternary-code DNA methylation dynamics: a new era for scalable mapping. Zhou Y, Huang Y. Cell Genomics 2025,5(9):101006.
A chemogenetic toolkit for inducible cell type-specific actin disassembly. Lan TH, Ambiel N, Zhou Y#, and Zuchero JB#. Small Methods. 2025,e2401522. Features as a Front-piece Cover Article. Optogenetic engineering for precision immunotherapy. Ke Y, Liu S, Huang Y, and Zhou Y#. Trends in Pharmacological Sciences. 2025,46(10):1018-37. (highlighted as a Cover Article)
Optogenetic engineering for ion channel modulation. Wang T, Nonomura T, Lan TH, and Zhou Y #. Current Opinion in Chemical Biology. 2025,85:102569. Heterochromatin deregulation during hematopoietic stem progenitor cell aging. Hong T, Guo L, Guzman A, You J, Goodell M, Zhou Y, and Huang Y. Cancer Research 85: IA011-IA011. Harnessing viral proteases for cellular and molecular engineering. Cui M, Tien-Hung Lan, and Zhou Y#. Chemistry-Methods. 2025,e202400098.
Optogenetic control of T cells for immunomodulation. McKee B, Liu S, Lan TH, and Zhou Y#. Essays in Biochemistry. 2025, EBC20253014. Modulation of ion channels with nanobodies.Sher A, Suris A, Huang Y, and Zhou Y#. Synthetic and Systems Biotechnology. 2025,10(2):593-9.
STIM1 and lipid interactions at ER-PM contact sites. Ke Y, Gannaban R, Liu J, and Zhou Y#. American Journal of Physiology – Cell Physiology. 2025,328(1):C107-C114.
Commissioned / In revision / Under review / In preparation
1. Liu X, Sher A, Lan TH, Wang D, McKee B, Zhao F, Zhu MX, Huang Y, Deng Q, Ma G, and Zhou Y#. Engineering of genetically encoded programmable CRAC channel blockers. Nature Communications 2025 (under review)
2. Ma G, Liu X, Lan TH, Duong T, Chiu M, Du D, Reiner DJ, Huang Y#, Ma G#, and Zhou Y#. A single-component optogenetic toolkit for programmable control of microtubule. Nature Communications 2025 (submitted)
3. Boone K, Ke Y, Jang H, Shi L, Zhou Y, and Reinhart-King C. Tools for cellular metabolic measurement and manipulation. Current Opinion in Biomedical Engineering. 2025 (under review)
4. Liu Z, Ke Y, Hong T, Smith K, Davies P, Huang Y, Zhang D, Chakraborty S, Zhou Y#, Wang F#. Ectopic FGFR1 increases intracellular pool of cholesterol in prostate cancer cells. Cancer Research (submitted)
5. Cui M, Wang T, Nonomura T, Wang T, and Zhou Y. Engineering orthogonal viral protease-embedded nanobodies for programmable gene circuits and cell-fate control. Cell Systems (submitted)
6. Nonomura T, McKee B, Wang T, and Zhou Y. De novo design of a caffeine-operated dissociation system. JACS (submitted)
7. Liu S, Wang T, Ke Y, Liu X, Ma G, and Zhou Y. Integrating genetically encoded CRAC channel blockers with CAR-T cells to improve therapeutic efficacy (CRAB-CAR). TiB (submitted)
8. Jing J, Ke Y, He L, and Zhou Y#. An optogenetic toolkit for precise control of subcellular organelles (LiSODA). In prep 9. Lan TH, Cui M, and Zhou Y#. Design of modular hybrid engineered recorders for tracking enzyme and protein activity (mHETZ). In prep 10. McKee B, Abdou A, Nonomura T, Huang Y, and Zhou Y#. Artificial intelligence (AI)-driven de novo protein design for therapeutic innovation. Medicinal Research Reviews. 2025 (commissioned)
8. Jing J, Ke Y, He L, and Zhou Y#. An optogenetic toolkit for precise control of subcellular organelles (LiSODA). In prep 9. Lan TH, Cui M, and Zhou Y#. Design of modular hybrid engineered recorders for tracking enzyme and protein activity (mHETZ). In prep 10. McKee B, Abdou A, Nonomura T, Huang Y, and Zhou Y#. Artificial intelligence (AI)-driven de novo protein design for therapeutic innovation. Medicinal Research Reviews. 2025 (commissioned)