2025 publications (17)
Repurposing salicylic acid as a versatile inducer of proximity.
Wang T, Liu S, Ke Y, Ali S, Wang R, Hong T, Liu Z, Ma G, Wang F, Zhu X, Huang Y, and Zhou Y#.
Nature Chemical Biology 2025,21(9):1444-56.
*Featured in Nature Chemical Biology News & Views: “A SAMBA for chemically induced proximity”. *Highlighted by Vital Record: "New research repurposes ancient remedy for blood cancer treatment". Highlighted by Futurity: “Common pain med ingredient could treat blood cancers”
Glycosphingolipids Regulate Phosphatidylserine Transport Machinery that Operates at ER-PM contact sites. Gannaban R, Ali S, Chen W, Nguyen M, Moore T, Zhou Y#, Hancock J#, Liu J#. Biorxiv 2025.09.27.678863 Access here. (in revision with Nat Commun)
RNA-mediated condensation of TFE3 oncofusions facilitates transcriptional hub formation to promote translocation renal cell carcinoma.
Guo L, Zhao R, Lee YT, Huang J, Wengler J, Rivera L, Hong T, Wang T, Rathod K, Suris A, Cai X, Wang R, Zhou Y#, and Huang Y#.
Nature Communications 2025,16(1):8712.
*Highlighted by Vital Record: "Disrupting cancer’s secret hubs: A new way to halt tumor growth". Highlighted by the The Academic Minute, Northeast Public Radio; Futurity: “‘Switch’ could turn off growth of tough childhood cancer”; Mirage News: “New strategy disrupts cancer hubs, halts tumor growth”; AZO Life Sciences: ”Disarming cancer’s droplet hubs to halt tumor growth”; ECancer: Disrupting cancer’s secret hubs: a new way to halt tumour growth”; Technology Networks: ”RNA hijacking revealed as engine of childhood kidney cancer”; ENTECH STEM Magazine’s Top 10 Biotechnology Discoveries and Innovations of 2025; ScienMag: “Uncovering tumor’s hidden networks: a novel strategy to stop cancer growth”; The Academic Minute @ WAMC Northeast Public Radio: “Inside the Cell’s Secret Droplets”; News-Medical.net: “Researchers engineer a tool to dismantle cancer's RNA-built growth hubs”; The Medical News: “Researchers engineer a tool to dismantle cancer’s RNA-built growth hubs”; Bioengineer.org: “Uncovering tumor’s hidden networks: a novel strategy to stop cancer growth”; SSBCrack NEWS: “Texas A&M Researchers Uncover RNA’s Role in Kidney Cancer Growth and Potential Treatment Strategy”
Engineering of photo-inducible binary interaction tools for biomedical applications. Lee YT, Guo L, Lan TH, Nonomura T, Liu G, Ma G, Wang R, Huang Y, and Zhou Y#. Nature Communications 2025,16(1):6940. *Highlighted by Vital Record: "Compact genetic light switches transform disease control". Featured by MIRAGE: “Genetic Light Switches Revolutionize Disease Control”; Featured by Bioengineer.org: “Genetic light switches revolutionize disease control”; Featured by Technology Networks: “Scientists Create Light-Activated Genetic Tools”; Highlighted in ScienMag: “Tiny Genetic Light Switches Revolutionize Disease Control”; Featured by Vital Record: “Compact genetic light switches transform disease control”; Featured by AZO Life Sciences: “PhoBITs Enable Unprecedented Control of Cellular Pathways with Blue Light” Reprogramming chemically induced dimerization systems with nanobody scaffolds. Wang T, Nonomura T, Cui M, Lan TH, Cai PX, He L, and Zhou Y. Chemical Science 2025,16:21774-80. Featured as a Cover Article. Access here. Featured by Vital Record: ”Brewing possibilities: Using caffeine to edit gene expression”; Featured by ScienTrek: “Caffeine-Controlled CRISPR Switches Gene Expression”; Highlighted by BioXconomy: “Thanks a latte: Using caffeine as an on switch for CRISPR”; Featured by Earth.com: “Caffeine could give scientists precise control over gene editing”; National Today: “Caffeine-Activated Gene Editing Could Lead to New Cancer Treatments” A single-component optogenetic toolkit for programmable control of microtubule. Ma G, Liu X, Lan TH, Duong T, Chiu M, Du D, Reiner DJ, Huang Y#, Ma G#, and Zhou Y#. Biorxiv 2025. Access here. [PMID: 41278679] Developing CRAC channel-based optogenetics to study calcium signaling processes. Nonomura T, Liu X, Chiu M, Tan Z, Lan Tien-Hung, and Zhou Y. Cold Spring Harbor Perspectives in Biology. 2025:a041760. Access here. Interrogating physiological functions with light and chemicals.Wang T, Zhang K, and Zhou Y#.Annual Review of Physiology. 2025. Access here Ternary-code DNA methylation dynamics: a new era for scalable mapping. Zhou Y, Huang Y. Cell Genomics 2025,5(9):101006.
A chemogenetic toolkit for inducible cell type-specific actin disassembly. Lan TH, Ambiel N, Zhou Y#, and Zuchero JB#. Small Methods. 2025,e2401522. Features as a Front-piece Cover Article. Optogenetic engineering for precision immunotherapy. Ke Y, Liu S, Huang Y, and Zhou Y#. Trends in Pharmacological Sciences. 2025,46(10):1018-37. (highlighted as a Cover Article)
Optogenetic engineering for ion channel modulation. Wang T, Nonomura T, Lan TH, and Zhou Y #. Current Opinion in Chemical Biology. 2025,85:102569. Heterochromatin deregulation during hematopoietic stem progenitor cell aging. Hong T, Guo L, Guzman A, You J, Goodell M, Zhou Y, and Huang Y. Cancer Research 85: IA011-IA011. Harnessing viral proteases for cellular and molecular engineering. Cui M, Tien-Hung Lan, and Zhou Y#. Chemistry-Methods. 2025,e202400098.
Optogenetic control of T cells for immunomodulation. McKee B, Liu S, Lan TH, and Zhou Y#. Essays in Biochemistry. 2025, EBC20253014. Modulation of ion channels with nanobodies.Sher A, Suris A, Huang Y, and Zhou Y#. Synthetic and Systems Biotechnology. 2025,10(2):593-9.
STIM1 and lipid interactions at ER-PM contact sites. Ke Y, Gannaban R, Liu J, and Zhou Y#. American Journal of Physiology – Cell Physiology. 2025,328(1):C107-C114.
Engineering of photo-inducible binary interaction tools for biomedical applications. Lee YT, Guo L, Lan TH, Nonomura T, Liu G, Ma G, Wang R, Huang Y, and Zhou Y#. Nature Communications 2025,16(1):6940. *Highlighted by Vital Record: "Compact genetic light switches transform disease control". Featured by MIRAGE: “Genetic Light Switches Revolutionize Disease Control”; Featured by Bioengineer.org: “Genetic light switches revolutionize disease control”; Featured by Technology Networks: “Scientists Create Light-Activated Genetic Tools”; Highlighted in ScienMag: “Tiny Genetic Light Switches Revolutionize Disease Control”; Featured by Vital Record: “Compact genetic light switches transform disease control”; Featured by AZO Life Sciences: “PhoBITs Enable Unprecedented Control of Cellular Pathways with Blue Light” Reprogramming chemically induced dimerization systems with nanobody scaffolds. Wang T, Nonomura T, Cui M, Lan TH, Cai PX, He L, and Zhou Y. Chemical Science 2025,16:21774-80. Featured as a Cover Article. Access here. Featured by Vital Record: ”Brewing possibilities: Using caffeine to edit gene expression”; Featured by ScienTrek: “Caffeine-Controlled CRISPR Switches Gene Expression”; Highlighted by BioXconomy: “Thanks a latte: Using caffeine as an on switch for CRISPR”; Featured by Earth.com: “Caffeine could give scientists precise control over gene editing”; National Today: “Caffeine-Activated Gene Editing Could Lead to New Cancer Treatments” A single-component optogenetic toolkit for programmable control of microtubule. Ma G, Liu X, Lan TH, Duong T, Chiu M, Du D, Reiner DJ, Huang Y#, Ma G#, and Zhou Y#. Biorxiv 2025. Access here. [PMID: 41278679] Developing CRAC channel-based optogenetics to study calcium signaling processes. Nonomura T, Liu X, Chiu M, Tan Z, Lan Tien-Hung, and Zhou Y. Cold Spring Harbor Perspectives in Biology. 2025:a041760. Access here. Interrogating physiological functions with light and chemicals.Wang T, Zhang K, and Zhou Y#.Annual Review of Physiology. 2025. Access here Ternary-code DNA methylation dynamics: a new era for scalable mapping. Zhou Y, Huang Y. Cell Genomics 2025,5(9):101006.
A chemogenetic toolkit for inducible cell type-specific actin disassembly. Lan TH, Ambiel N, Zhou Y#, and Zuchero JB#. Small Methods. 2025,e2401522. Features as a Front-piece Cover Article. Optogenetic engineering for precision immunotherapy. Ke Y, Liu S, Huang Y, and Zhou Y#. Trends in Pharmacological Sciences. 2025,46(10):1018-37. (highlighted as a Cover Article)
Optogenetic engineering for ion channel modulation. Wang T, Nonomura T, Lan TH, and Zhou Y #. Current Opinion in Chemical Biology. 2025,85:102569. Heterochromatin deregulation during hematopoietic stem progenitor cell aging. Hong T, Guo L, Guzman A, You J, Goodell M, Zhou Y, and Huang Y. Cancer Research 85: IA011-IA011. Harnessing viral proteases for cellular and molecular engineering. Cui M, Tien-Hung Lan, and Zhou Y#. Chemistry-Methods. 2025,e202400098.
Optogenetic control of T cells for immunomodulation. McKee B, Liu S, Lan TH, and Zhou Y#. Essays in Biochemistry. 2025, EBC20253014. Modulation of ion channels with nanobodies.Sher A, Suris A, Huang Y, and Zhou Y#. Synthetic and Systems Biotechnology. 2025,10(2):593-9.
STIM1 and lipid interactions at ER-PM contact sites. Ke Y, Gannaban R, Liu J, and Zhou Y#. American Journal of Physiology – Cell Physiology. 2025,328(1):C107-C114.