2017 publications (14)
Optogenetic immunomodulation: shedding light on the immune system.
Tan P, He L, Han G, Zhou Y#.
Trends in Biotechnology. 2017,35(3):215-26. Optics & Photonics News: “Cancer Immunotherapy: The Optogenetics Angle”
The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors.
Lin A, Hu Q, Li C, Xing Z, Ma G, Wang C, Li J, Yao J, Ke L, Wang S, Park P, Marks J, Zhou Y, Zhou J, Heung MC, Liang H, Hu Z, Shen H, Hawke DH, Han L, Zhou Y#, Lin C#, and Yang L#.
Nature Cell Biology. 2017,19(3):238-51. Highlighted in Nature Reviews Molecular Cell Biology: “Then cancer link(RNA) between PIP3 and AKT”
Mutations in 5-methylcytosine oxidase TET2 and RHOA cooperatively disrupt T cell homeostasis.
Zang S, Li J, Yang H, Zeng H, Han W, Zhang J, Lee M, Moczygemba M, Isgandarova S, Yang Y, Zhou Y, Rao A, You MJ, Sun D, Huang Y.
Journal of Clinical Investigation. 2017,127(8):2998-3012. A novel animal model recapitulating hallmark human PTCL pathology and symptoms; Vital Records: “Research determines mechanism, moves closer toward possible therapy for type of lymphoma”
Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein.
Lei Y, Zhang X, Su J, Jeong M, Gundry MC, Huang YH, Zhou Y, Li W and Goodell MA.
Nature Communications. 2017,8:16026. First report of a precise DNA methylation editing tool based on CRISPR/Cas9
Engineered split-TET2 enzyme for inducible epigenetic remodeling.
Lee M, Li J, Liang Y, Ma G, Zhang J, He L, Liu Y, Li M, Sun D, Zhou Y# and Huang Y#.
Journal of the American Chemical Society. 2017,139(13):4659-62. Highlighted in ACS Editors’ Choice ; JACS Spotlights: “Epigenetic Changes on Demand with an Enzyme–Small Molecule Combo”; Vital Records: “Epigenetic changes on demand: tuning the ‘traffic lights’ of DNA from red to green”
Optogenetic control of membrane tethering and interorganellar communication at nanoscales. He L, Jing J, Zhu L, Tan P, Ma G, Nhung NT, Wang J#, Zhou Y#, and Huang Y#. Chemical Science. 2017,8(8):5275-81. Highlighted as Cover Article @ Royal Society of Chemistry; Vital Record: “Building bridges within the cell – using light”; Asian Scientist Magazine: “Using light to build bridges in cells”; Featured in NIH Biomedical Beat: “Optogenetics sparks new research tools”; BioTechniques Breaking News: “Building an Optogenetic Bridge Between Membranes”; Photonics Media: “Optogenetics controls interorganellar communication at nanoscale”; Science Daily News: “How a new technique allows researchers to tune communication between organelles”
cybLuc: an effective aminoluciferin derivative for deep bioluminescence imaging. Wu W, Su J, Tang C, Bai H, Ma Z, Zhang T, Yuan Z, Li Z, Zhou W, Zhou H, Liu Z, Wang Y, Zhou Y, D L, Gu L, Li M. Analytical Chemistry. 2017,8:428-32.
Integrated pipeline for inferring the evolutionary history of a gene family embedded in the species tree: a case study on the STIMATE gene family. Song J, Zheng S, Nguyen NT, Wang Y, Zhou Y and Lin K. BMC Bioinformatics. 2017,18(1): 439.
An engineered split-TET2 enzyme for chemical-inducible DNA hydroxymethylation and epigenetic remodeling. Li, M, Zhou Y# and Huang Y#. Journal of Visualized Experiments. 2017 (130), e56858.
New bioluminescent coelenterazine derivatives with various C-6 substitutions. Jiang T, Yang X, Zhou Y, Yampolsky IV, Du L and Li M. Organic & Biomolecular Chemistry. 2017,15(33):7008-18.
Discovery of the first environment-sensitive fluorescent probe for GPR120 (FFA4) imaging. Liu J, Tian C, Jiang T, Gao Y, Zhou Y, Li M and Du L. ACS Medicinal Chemistry Letters. 2017,8:428-32.
Molecular determinants for STIM1 activation during store-operated Ca2+ entry. Ma G, Zheng S, Ke Y, Zhou L, He L, Huang Y, Wang Y and Zhou Y#. Current Molecular Medicine. 2017,17(1):60-9. Highlighted in CMM Editor’s Choice & Cover Article; News-MEDICAL: "Researchers gain new insights into factors crucial for STIM1 activation"; EurekAlert! AAAS: "Critical molecular determinants for activation of calcium influx into cells revealed"
TET1-mediated oxidation of 5-formylcytosine to 5-carboxycytosine in RNA. Basanta-Sanchez M, Wang R, Liu Z, Ye X, Li M, Shi X, Agris PF, Zhou Y, Huang Y, and Sheng J. ChemBioChem. 2017,18(1):72-6. Optogenetic toolkit for precise control of calcium signaling. Ma G, Wen S, Huang Y, Wang Y and Zhou Y#. Cell Calcium. 2017,64:36-46.
Optogenetic control of membrane tethering and interorganellar communication at nanoscales. He L, Jing J, Zhu L, Tan P, Ma G, Nhung NT, Wang J#, Zhou Y#, and Huang Y#. Chemical Science. 2017,8(8):5275-81. Highlighted as Cover Article @ Royal Society of Chemistry; Vital Record: “Building bridges within the cell – using light”; Asian Scientist Magazine: “Using light to build bridges in cells”; Featured in NIH Biomedical Beat: “Optogenetics sparks new research tools”; BioTechniques Breaking News: “Building an Optogenetic Bridge Between Membranes”; Photonics Media: “Optogenetics controls interorganellar communication at nanoscale”; Science Daily News: “How a new technique allows researchers to tune communication between organelles”
cybLuc: an effective aminoluciferin derivative for deep bioluminescence imaging. Wu W, Su J, Tang C, Bai H, Ma Z, Zhang T, Yuan Z, Li Z, Zhou W, Zhou H, Liu Z, Wang Y, Zhou Y, D L, Gu L, Li M. Analytical Chemistry. 2017,8:428-32.
Integrated pipeline for inferring the evolutionary history of a gene family embedded in the species tree: a case study on the STIMATE gene family. Song J, Zheng S, Nguyen NT, Wang Y, Zhou Y and Lin K. BMC Bioinformatics. 2017,18(1): 439.
An engineered split-TET2 enzyme for chemical-inducible DNA hydroxymethylation and epigenetic remodeling. Li, M, Zhou Y# and Huang Y#. Journal of Visualized Experiments. 2017 (130), e56858.
New bioluminescent coelenterazine derivatives with various C-6 substitutions. Jiang T, Yang X, Zhou Y, Yampolsky IV, Du L and Li M. Organic & Biomolecular Chemistry. 2017,15(33):7008-18.
Discovery of the first environment-sensitive fluorescent probe for GPR120 (FFA4) imaging. Liu J, Tian C, Jiang T, Gao Y, Zhou Y, Li M and Du L. ACS Medicinal Chemistry Letters. 2017,8:428-32.
Molecular determinants for STIM1 activation during store-operated Ca2+ entry. Ma G, Zheng S, Ke Y, Zhou L, He L, Huang Y, Wang Y and Zhou Y#. Current Molecular Medicine. 2017,17(1):60-9. Highlighted in CMM Editor’s Choice & Cover Article; News-MEDICAL: "Researchers gain new insights into factors crucial for STIM1 activation"; EurekAlert! AAAS: "Critical molecular determinants for activation of calcium influx into cells revealed"
TET1-mediated oxidation of 5-formylcytosine to 5-carboxycytosine in RNA. Basanta-Sanchez M, Wang R, Liu Z, Ye X, Li M, Shi X, Agris PF, Zhou Y, Huang Y, and Sheng J. ChemBioChem. 2017,18(1):72-6. Optogenetic toolkit for precise control of calcium signaling. Ma G, Wen S, Huang Y, Wang Y and Zhou Y#. Cell Calcium. 2017,64:36-46.