2026 publications
Accepted, Under Revision, Submitted, or Works in Preparation
Interrogating cell physiology with light and chemicals.
Wang T, Zhang K, and Zhou Y#.
Annual Review of Physiology. 2026, 88:14.1-14.26.
Engineering of genetically encoded programmable CRAC channel blockers.
Liu X, Sher A, Lan TH, Wang D, McKee B, Zhao F, Zhu MX, Huang Y, Deng Q, Ma G, and Zhou Y#.
Nature Communications (under review).
A single-component optogenetic toolkit for programmable control of microtubule.
Ma G, Liu X, Lan TH, Duong T, Chiu M, Du D, Reiner DJ, Huang Y#, Ma G#, and Zhou Y#.
Nature Communications (submitted). BioRxiv link.
Tools for cellular metabolic measurement and manipulation.
Boone K, Ke Y, Jang H, Shi L, Zhou Y, and Reinhart-King C.
Current Opinion in Biomedical Engineering. (under review)
Ectopic FGFR1 increases intracellular pool of cholesterol in prostate cancer cells.
Liu Z, Ke Y, Hong T, Smith K, Davies P, Huang Y, Zhang D, Chakraborty S, Zhou Y#, Wang F#.
Cancer Research (submitted)
Engineering orthogonal viral protease-embedded nanobodies for programmable gene circuits and cell-fate control.
Cui M, Wang T, Nonomura T, Wang T, and Zhou Y.
Cell Systems (submitted)
AI-powered de novo design of a caffeine-operated dissociation system.
Nonomura T, McKee B, Wang T, and Zhou Y.
JACS (submitted)
Engineering CAR-T Cells with a calcium channel–modulating peptide to enhance efficacy and safety (CaMP-CAR).
Liu S, Wang T, Ke Y, Liu X, Ma G, Lan TH, and Zhou Y.
TiB (submitted)
Jing J, Ke Y, He L, and Zhou Y#. An optogenetic toolkit for precise control of subcellular organelles (LiSODA). In prep Lan TH, Cui M, and Zhou Y#. Design of modular hybrid engineered recorders for tracking enzyme and protein activity (mHETZ). In prep Artificial intelligence (AI)-driven de novo protein design for therapeutic innovation. McKee B, Abdou A, Nonomura T, Huang Y, and Zhou Y#. Medicinal Research Reviews. 2025 (commissioned) Illuminating the Cytoskeleton: Optical Probes and Optogenetic Tools for Spatiotemporal Interrogation of Cytoskeletal Dynamics. Du D, Liu X, Lan TH, and Zhou Y#. Bioconjugate Chemistry. 2025 (commissioned) Chemically inducible dimerization systems. Nonomura T, Wang T, and Zhou Y#. Chemistry – A European Journal. 2025 (commissioned) Molecular tools to interrogate membrane contact sites. Ke Y, Sher A, Liu J, and Zhou Y. Contact. 2025 (commissioned) Molecular tools for precise control of cellular events. Chan HM, Nonomura T, and Zhou Y. RSC Chemical Biology. 2025 (commissioned) Genetically encoded systems for induced protein proximity: mechanisms, design principles, and therapeutic applications. Nonomura T, Price A, Wang T, and Zhou Y. Pharmacology & Therapeutics. 2025 (commissioned) 17. Wang T, Nonomura T, Cui M, Lan TH, and Zhou Y#. Engineering of viral protease-based inducible oligomerization tool (VIPoligo). In prep 18. Ke Y, Cui M, Nonomura T, Wang T#, and Zhou Y#. Engineering vitamin-responsive devices for programmable protein association and dissociation (VitaPAD). In prep
19. Lan TH, Nonomura T, Cui M, McKee B, Ke Y, and Zhou Y. Engineering of Inducible Cold-triggered control of Protein Allostery and Dynamics (ICEPAD)” (IcePAD). In prep 20. Nonomura T, McKee B, Cui M, Sher A, Wang T, Lan TH, and Zhou Y#. De novo design of peptide-based calcium channel modulators (PeCaMP) for disease intervention. In prep 21. Nonomura T, Wang T, Cui M, Lan TH, and Zhou Y. A LOV2-Based Photoswitchable Platform for Programmable Oligomerization (LOVoligo). In prep 22. Sher A, Liu X, Ma G, Tan Z, and Zhou Y. Optogenetic screening of calcium channel inhibitors for immunomodulation (CRACi). In prep 23. Lan TH, Cui M, Ke Y, Nonomura T, Mckee B, and Zhou Y. Design of Transmembrane Receptor-Aided Protein Internalization Tools (TRAPIT). In prep 24. Nonomura T, McKee B, Cui M, Sher A, Wang T, Lan TH, and Zhou Y. Artificial intelligence-aided de novo design of Calcium-Modulating Polypeptides (DeCAMP). In prep 25. Wang T, McKee B, Nonomura T, Cui M, Lan TH, and Zhou Y. Design of de novo Regulators for Uncoupling of Molecular Binary Association (RUBMA). In prep 26. Nonomura T, McKee B, Ke Y, Wang T, and Zhou Y. Design of Caffeine Metabolite–driven Oligomerization and Control of Heteromeric Association tools (cMOCHA). In prep 27. Ke Y, Wang T, Nonomura T, and Zhou Y. Design of Neo-Engineered Oncotarget Surface for Universal Redirection of Functionalized CAR-T cells (NEOSURF). In prep 28. Nonomura T, McKee B, Wang T, and Zhou Y. Ligand-responsive Allosteric Tools for Tunable Engagement of target proteins (LATTE). In prep 29. Lan TH, Cui M, Nonomura T, and Zhou Y. Engineering of Orthogonal peptide-engaged receptor activation/actuation system (OPERAS). In prep 30. Lan TH, Cui M, Nonomura T, and Zhou Y. Design of Synthetic ENgineered Transmembrane Receptor for Ligand-sensing (SENTRYL). In prep
Jing J, Ke Y, He L, and Zhou Y#. An optogenetic toolkit for precise control of subcellular organelles (LiSODA). In prep Lan TH, Cui M, and Zhou Y#. Design of modular hybrid engineered recorders for tracking enzyme and protein activity (mHETZ). In prep Artificial intelligence (AI)-driven de novo protein design for therapeutic innovation. McKee B, Abdou A, Nonomura T, Huang Y, and Zhou Y#. Medicinal Research Reviews. 2025 (commissioned) Illuminating the Cytoskeleton: Optical Probes and Optogenetic Tools for Spatiotemporal Interrogation of Cytoskeletal Dynamics. Du D, Liu X, Lan TH, and Zhou Y#. Bioconjugate Chemistry. 2025 (commissioned) Chemically inducible dimerization systems. Nonomura T, Wang T, and Zhou Y#. Chemistry – A European Journal. 2025 (commissioned) Molecular tools to interrogate membrane contact sites. Ke Y, Sher A, Liu J, and Zhou Y. Contact. 2025 (commissioned) Molecular tools for precise control of cellular events. Chan HM, Nonomura T, and Zhou Y. RSC Chemical Biology. 2025 (commissioned) Genetically encoded systems for induced protein proximity: mechanisms, design principles, and therapeutic applications. Nonomura T, Price A, Wang T, and Zhou Y. Pharmacology & Therapeutics. 2025 (commissioned) 17. Wang T, Nonomura T, Cui M, Lan TH, and Zhou Y#. Engineering of viral protease-based inducible oligomerization tool (VIPoligo). In prep 18. Ke Y, Cui M, Nonomura T, Wang T#, and Zhou Y#. Engineering vitamin-responsive devices for programmable protein association and dissociation (VitaPAD). In prep
19. Lan TH, Nonomura T, Cui M, McKee B, Ke Y, and Zhou Y. Engineering of Inducible Cold-triggered control of Protein Allostery and Dynamics (ICEPAD)” (IcePAD). In prep 20. Nonomura T, McKee B, Cui M, Sher A, Wang T, Lan TH, and Zhou Y#. De novo design of peptide-based calcium channel modulators (PeCaMP) for disease intervention. In prep 21. Nonomura T, Wang T, Cui M, Lan TH, and Zhou Y. A LOV2-Based Photoswitchable Platform for Programmable Oligomerization (LOVoligo). In prep 22. Sher A, Liu X, Ma G, Tan Z, and Zhou Y. Optogenetic screening of calcium channel inhibitors for immunomodulation (CRACi). In prep 23. Lan TH, Cui M, Ke Y, Nonomura T, Mckee B, and Zhou Y. Design of Transmembrane Receptor-Aided Protein Internalization Tools (TRAPIT). In prep 24. Nonomura T, McKee B, Cui M, Sher A, Wang T, Lan TH, and Zhou Y. Artificial intelligence-aided de novo design of Calcium-Modulating Polypeptides (DeCAMP). In prep 25. Wang T, McKee B, Nonomura T, Cui M, Lan TH, and Zhou Y. Design of de novo Regulators for Uncoupling of Molecular Binary Association (RUBMA). In prep 26. Nonomura T, McKee B, Ke Y, Wang T, and Zhou Y. Design of Caffeine Metabolite–driven Oligomerization and Control of Heteromeric Association tools (cMOCHA). In prep 27. Ke Y, Wang T, Nonomura T, and Zhou Y. Design of Neo-Engineered Oncotarget Surface for Universal Redirection of Functionalized CAR-T cells (NEOSURF). In prep 28. Nonomura T, McKee B, Wang T, and Zhou Y. Ligand-responsive Allosteric Tools for Tunable Engagement of target proteins (LATTE). In prep 29. Lan TH, Cui M, Nonomura T, and Zhou Y. Engineering of Orthogonal peptide-engaged receptor activation/actuation system (OPERAS). In prep 30. Lan TH, Cui M, Nonomura T, and Zhou Y. Design of Synthetic ENgineered Transmembrane Receptor for Ligand-sensing (SENTRYL). In prep