2026 publications
In Press or Accepted (4), Under Revision (4), Commissioned (7), Under review or Submitted (5), or In Preparation (20+)
Interrogating cell physiology with light and chemicals.
Wang T, Zhang K, and Zhou Y#.
Annual Review of Physiology. 2026,88:21-46. Access here.
Early driver, late bystander: stage-specific roles of DNMT3A-R882 mutations unveiled in human AML.Zhou Y, and Huang Y. Cancer Discovery. 2026. (in press)
Recent advances in optical tools for measurement and manipulation of oncogenic cellular metabolism.Boone K, Ke Y, Jang H, Shi L, Zhou Y, and Reinhart-King C.
Current Opinion in Biomedical Engineering. 2026,37:100647.
Engineering of genetically encoded programmable CRAC channel inhibitors.
Liu X, Sher A, Lan TH, Wang D, McKee B, Zhao F, Zhu MX, Huang Y, Deng Q, Ma G, and Zhou Y.
Nature Communications. (in revision).
Engineering viral protease-operated nanobodies for programmable and orthogonal control of protein function.
Cui M, Liu X, Wang T, Lan TH, Nonomura T, Wang R, Huang Y, and Zhou Y.
Nature Communications. (in revision)
Glycosphingolipids Regulate Phosphatidylserine Transport Machinery that Operates at ER-PM contact sites. Gannaban R, Ali S, Chen W, Nguyen M, Moore T, Zhou Y#, Hancock J#, Liu J#.
Nature Communications. (in revision).
A single-component optogenetic toolkit for programmable control of microtubule.
Ma G, Liu X, Lan TH, Duong T, Chiu M, Du D, Reiner DJ, Huang Y#, Ma G#, and Zhou Y#.
Advanced Science. (under consideration). BioRxiv link.
AI-driven de novo design of a caffeine-operated dissociation system (CODS). Nonomura T, McKee B, Price A, Wang T, and Zhou Y. JACS (under review)
Ectopic FGFR1 increases intracellular pool of cholesterol in prostate cancer cells.
Liu Z, Ke Y, Hong T, Smith K, Davies P, Huang Y, Zhang D, Chakraborty S, Zhou Y#, Wang F#.
International Journal of Molecular Sciences. 2026,27(3):1190.
Phage display driven identification and computational mapping of macrocyclic peptides targeting RhoA G17V. Abrahama S, Zhua C, Le L, Yugendar R. Alugubelli A, Nonomura T, Huang Y. Hamptona T, Zhou Y#, Liu W# Biochemistry (under review)
Engineering CAR-T Cells with a calcium channel–modulating peptide to enhance efficacy and safety (CaMP-CAR).
Liu S, Wang T, Ke Y, Liu X, Ma G, Lan TH, and Zhou Y.
Trends in Biotechnology (In prep)
A modular optogenetic toolkit for light-driven manipulation of subcellular organelles (LiSODA).
Jing J, He L, Lan TH, Huang Y, and Zhou Y#.
Science Advances (In prep)
Optical probes and optogenetic tools for spatiotemporal interrogation of cytoskeletal dynamics.
Du D, Liu X, Lan TH, and Zhou Y#.
Bioconjugate Chemistry. 2026 (commissioned)
Chemically inducible dimerization systems.
Nonomura T, Wang T, and Zhou Y#.
Chemistry – A European Journal. 2026 (commissioned)
Molecular tools to interrogate membrane contact sites.
Ke Y, Sher A, Liu J, and Zhou Y.
Contact. 2026 (commissioned)
Molecular tools for precise control of cellular events.
Chan HM, Nonomura T, and Zhou Y.
RSC Chemical Biology. 2026 (commissioned)
Genetically encoded systems for induced protein proximity.
Nonomura T, Price A, Wang T, and Zhou Y.
Pharmacology & Therapeutics. 2026 (commissioned)
Artificial intelligence (AI)-driven de novo protein design for therapeutic innovation.
McKee B, Abdou A, Nonomura T, Huang Y, and Zhou Y#.
Medicinal Research Reviews. 2026 (commissioned)
Novel chemogenetic approaches in modulating calcium signaling.
Price A, Zhou Y#, Lan TB#.
Biomedical Society Transactions. 2026 (commissioned)
Design of modular hybrid engineered recorders for tracking enzyme and protein activity (mHERTZ). Lan TH, Cui M, and Zhou Y#. In prep
Engineering of viral protease and binder-programmed dissembly by reversible oligomerization perturbation (VIPDrop). Wang T, McKee B, Nonomura T, Cui M, Lan TH, and Zhou Y#. In prep
Engineering of viral protease-based inducible oligomerization tool (VIPoligo).
Wang T, Nonomura T, McKee B, Cui M, Lan TH, and Zhou Y#.
In prep
Engineering vitamin-responsive devices for programmable protein association and dissociation (VitaPAD).
Ke Y, Cui M, Nonomura T, Wang T#, and Zhou Y#.
In prep
Engineering of Inducible Cold-Enabled Protein Association Tools via de novo Design (IcePAD). Nonomura T, Price A, McKee B, Lan TH, Cui M, Ke Y, and Zhou Y. In prep
Engineering of Falling-temperature Responsive On-demand Switching Tool for Allosteric Modulation (FROST)Lan TH, Nonomura T, Cui M, McKee B, Ke Y, and Zhou Y.
In prep
A LOV2-Based Photoswitchable Platform for Programmable Oligomerization (LOVoligo).
Nonomura T, Wang T, Cui M, Lan TH, and Zhou Y.
In prep
Optogenetic screening of calcium channel inhibitors for immunomodulation (CRACi).
Sher A, Liu X, Ma G, Tan Z, and Zhou Y.
In prep
CaMbody: Engineering of Ca2+-modulated single-domain antibody. Liu S, Wang T, Huang Y, and Zhou Y#. In prep Identification of an ER calcium regulator that drives store depletion and pathological T cell activation in lymphoma Ke Y ,Wang Q, Sher A, Zhu M, and Zhou Y Design of Transmembrane Receptor-Aided Protein Internalization Tools (TRAPIT). Lan TH, Cui M, Ke Y, Nonomura T, Mckee B, and Zhou Y. In prep De novo design of peptide-based calcium channel modulators (PeCaMP) for disease intervention. Nonomura T, McKee B, Cui M, Sher A, Wang T, Lan TH, and Zhou Y#. In prep Artificial intelligence-aided de novo design of Calcium-Modulating Polypeptides (DeCAMP). Nonomura T, McKee B, Cui M, Sher A, Wang T, Lan TH, and Zhou Y. In prep Engineering of repurposed metabolic GPCR- and beta-arrestin-based actuation system (RUBMA). Cui M, Lan TH, and Zhou Y. In prep DISCO: Design of a Dissociation Induced by Salicylic-acid Chemical Operation Tool Wang T, Nonomura T, Cui M, Zhou Y. In prep Design of Caffeine Metabolite–driven Oligomerization and Control of Heteromeric Association tools (cMOCHA). Nonomura T, McKee B, Ke Y, Wang T, and Zhou Y. In prep MELODY: Engineering of dietary supplement-responsive CAR-T cells. Lan TH, Cui M, Wang T, Huang Y, and Zhou Y#. In prep Design of an acidic lactate–operated homeostatic actuator system (ALOHA). Lan TH, Cui M, Ke Y, Wang T, and Zhou Y. In prep AROMA: Aromatic amino acid-operated molecular association system. Cui M, Lan TH, Wang T, and Zhou Y. In prep Repurposing photoswitchable domains for chemogenetic control of protein function.Cui M, Lan TH, and Zhou Y#. In prep Design of Neo-Engineered Oncotarget Surface for Universal Redirection of Functionalized CAR-T cells (NEOSURF). Ke Y, Wang T, Nonomura T, and Zhou Y. In prep Ligand-responsive Allosteric Tools for Tunable Engagement of target proteins (LATTE). Nonomura T, McKee B, Wang T, and Zhou Y. In prep Engineering of Orthogonal peptide-engaged receptor activation/actuation system (OPERAS). Lan TH, Cui M, Nonomura T, and Zhou Y. In prep Design of Synthetic ENgineered Transmembrane Receptor for Ligand-sensing (SENTRYL). Lan TH, Cui M, Nonomura T, and Zhou Y. In prep
CaMbody: Engineering of Ca2+-modulated single-domain antibody. Liu S, Wang T, Huang Y, and Zhou Y#. In prep Identification of an ER calcium regulator that drives store depletion and pathological T cell activation in lymphoma Ke Y ,Wang Q, Sher A, Zhu M, and Zhou Y Design of Transmembrane Receptor-Aided Protein Internalization Tools (TRAPIT). Lan TH, Cui M, Ke Y, Nonomura T, Mckee B, and Zhou Y. In prep De novo design of peptide-based calcium channel modulators (PeCaMP) for disease intervention. Nonomura T, McKee B, Cui M, Sher A, Wang T, Lan TH, and Zhou Y#. In prep Artificial intelligence-aided de novo design of Calcium-Modulating Polypeptides (DeCAMP). Nonomura T, McKee B, Cui M, Sher A, Wang T, Lan TH, and Zhou Y. In prep Engineering of repurposed metabolic GPCR- and beta-arrestin-based actuation system (RUBMA). Cui M, Lan TH, and Zhou Y. In prep DISCO: Design of a Dissociation Induced by Salicylic-acid Chemical Operation Tool Wang T, Nonomura T, Cui M, Zhou Y. In prep Design of Caffeine Metabolite–driven Oligomerization and Control of Heteromeric Association tools (cMOCHA). Nonomura T, McKee B, Ke Y, Wang T, and Zhou Y. In prep MELODY: Engineering of dietary supplement-responsive CAR-T cells. Lan TH, Cui M, Wang T, Huang Y, and Zhou Y#. In prep Design of an acidic lactate–operated homeostatic actuator system (ALOHA). Lan TH, Cui M, Ke Y, Wang T, and Zhou Y. In prep AROMA: Aromatic amino acid-operated molecular association system. Cui M, Lan TH, Wang T, and Zhou Y. In prep Repurposing photoswitchable domains for chemogenetic control of protein function.Cui M, Lan TH, and Zhou Y#. In prep Design of Neo-Engineered Oncotarget Surface for Universal Redirection of Functionalized CAR-T cells (NEOSURF). Ke Y, Wang T, Nonomura T, and Zhou Y. In prep Ligand-responsive Allosteric Tools for Tunable Engagement of target proteins (LATTE). Nonomura T, McKee B, Wang T, and Zhou Y. In prep Engineering of Orthogonal peptide-engaged receptor activation/actuation system (OPERAS). Lan TH, Cui M, Nonomura T, and Zhou Y. In prep Design of Synthetic ENgineered Transmembrane Receptor for Ligand-sensing (SENTRYL). Lan TH, Cui M, Nonomura T, and Zhou Y. In prep