2020 publications (13)
Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling. Ma G, He L, Liu S, Xie J, Huang Z, Jing J, Lee, YT, Wang R, Luo H, Han W, Huang Y and Zhou Y#. Nature Communications. 2020,11(1):1039. * Opto-CARC tools highlighted by Addgene Blog: “Harnessing the Body’s Defenses to Fight Cancer”; *Highlighted in Commentary by Cell Calcium: “Natural photoswitches expose STIM1 activation steps” A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi resistant leukemia cells. Guo L, Li J, Zeng H, Guzman A, Li T, Lee M, Zhou Y, Stefan C, Goodell MA, Stephan C, Davies PJA, Dawson M, Sun D, and Huang Y. Nature Communications. 2020,11:740. First proof-of-concept to target enhancer plasticity to treat BETi resistant leukemia Intelligent cell-based therapies for cancer and autoimmune disorders. Rui Chen, Ji Jing, Siwko SK, Zhou Y#. Current Opinion in Biotechnology. 2020,66,207-12.
Optogenetic approaches to control Ca2+-modulated physiological processes. Nguyen NT, Guolin Ma, Zhou Y#, and Jing J#. Current Opinion in Physiology. 2020,17:187-96. Optical control of CRAC channel using photoswitchable azopyrazoles. Yang X, Ma G, Zheng S, Qin X, Li X, Du L, Wang Y#, Zhou Y#, and Li M#. Journal of the American Chemical Society. 2020,142(20):9460-9470. *Featured by JACS as a Cover Article; First photopharmacological tool to control the CRAC channel in vivo Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma. Li, J, Zhao S, Lee M, Yin Y, Li J, Zhou Y, Ballester LY, Esquenazi Y, Dashwood RH, Davies PJA, Parsons DW, Li XN, Huang Y, and Sun D. Science Advances. 2020,6:eabb5427. *Highlighted in Vital Records; “Scientists develop highly effective tumor detection strategy for common childhood brain tumors”; *First comprehensive bioinformatic analysis on the functions of heat shock protein family in cancer
Characterization of the dual functional effects of heat shock proteins (HSPs) in cancer hallmarks to aid development of HSP inhibitors. Zhang Z, Jing J, Ye Y, Chen Z, Jing Y, Li S, Hong W, Ruan H, Liu Y, Hu Q, Huang Y, Li W, Lin C, Diao L, Zhou Y#, and Han L#. Genome Medicine. 2020,12(1):101.
Expanding the repertoire of chemogenetic toolbox by circular permutation. Lee YT, He L, and Zhou Y#. Journal of Molecular Biology. 2020,432(10):3127-36.
RPL32 promotes lung cancer progression by facilitating p53 degradation. Xie J, Zhang W, Liang X, Shuai C, Zhou Y, Pan H, Yang Y, and Han W. Molecular Therapy - Nucleic Acids. 2020. 21:75-85.
Visible light excited ratiometric-GECIs for long-term in-cellulo monitoring of calcium signals. Li J, Wang L, Chen Y, Yang Y, Liu J, Liu K, Lee YT, He N, Zhou Y, and Wang Y. Cell Calcium. 2020,87:102165.
A STIMulating journey into optogenetic engineering. Ma G, and Zhou Y#. Cell Calcium. 2020,88:102197.
RNA modifications and cancer. Haruehanroengra P, Zheng YY, Zhou Y, Huang Y and Sheng J. RNA Biology. 2020:1-16.
A molecular toolbox for interrogation of membrane contact sites. Jing J, Liu G, Y Huang and Zhou Y#. Journal of Physiology. 2020,598(9):1725-39. *Highlighted as “Editor’s Choice”; Ranked as “Top downloaded paper”