2021 publications (16)
Nano-optogenetic engineering of CAR T-cells for precision immunotherapy with enhanced safety.
Nguyen NT, Huang K, Zeng H, Jing J, Wang R, Fang S, Chen J, Liu X, Huang Z, You JM, Rao A, Huang Y, Han G, Zhou Y#.
Nature Nanotechnology. 2021,16(12):1424-34. *STAT+ NEWS: ”In research on mice, scientists use light to paint a more precise target for CAR-T to attack tumors”; *Highlighted by Clinical Leader: “Shining light on the commercial potential of optogenetic therapies”
Circularly permuted LOV2 as a modular domain for optogenetic engineering. He L, Tan P, Zhu L, Huang L, Nguyen NT, Huang Y, Han G, Wang J, Zhou Y#. Nature Chemical Biology. 2021,17(8):915-23. *First report of LOV2 circular permutants for design of light-switchable CAR T-cells; *Featured in Nature Portfolio – Chemical Tools Collection; Highlighted as “Paper of the Month” by OptoBase; *Highlighted by Optics and Photonics News:”Modular blue light-sensitive photoswitch developed for optogenetic engineering”; *Recommended by Faculty Opinion (9.3/10; top 0.5% in Chemical Biology): 10.3410/f.740063208.793587708 Expression of chimeric antigen receptor therapy targets detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity. Jing Y, Liu Y, Li Q, Ye Y, Diao L, Huang Y, Zhou Y, Green MR, Mills GB, and Han L. Cancer Cell. 2021,39(12):1558-9.
Engineering of a bona fide light-operated calcium channel. He L, Wang L, Zeng H, Tan P, Ma G, Zheng S, Li Y, Sun L, Dou F, Huang Y, Wang Y, and Zhou Y#. Nature Communications. 2021,12:164. *Highlighted in Commentary by Cell Calcium: “Blue light opens the ORAI1 LOC(K)”; *Featured in Nature Communications Editor’s Highlights “Biotechnology and methods”
Optogenetic control of non-apoptotic cell death. He L, Huang Z, Huang K, Chen R, Nguyen NT, Wang R, Cai X, Huang Z, Siwko S, Walker JR, Han G#, Zhou Y#, and Jing J#. Advanced Science. 2021,2100424. (IF: 16.806) * Highlighted as a Cover Article; Collaboration with Promega for first demonstration of NanoLuc based wireless optogenetics Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility. Ma T, Huang Z, Xie X, Zhuang X, Childs M, Gangal H, Wang X, Smith LN, Smith R, Zhou Y, and Wang J. Journal of Clinical Investigation. 2021,e154969. Caffeine-operated synthetic modules for chemogenetic control of protein activities by life style. Wang T, He L, Jing J, Lan TH, Hong T, Wang F, Huang Y, Ma G, and Zhou Y#. Advanced Science. 2021,8(3):2002148. *Highlighted as a Cover Article; Featured by Vital Record: “Using caffeine to ward off disease” *Interview with KBTX News 3 Channel: “Researchers at Texas A&M using caffeine to help fight off viruses like COVID-19”
TET2 inactivation enhances the anti-tumor activity of tumor-infiltrating lymphocytes. Lee MJ, Li J, Fang S, Zhang J, Vo AT, Han W, Zeng H, Isgandarova S, Martinze-Moczygemba M, Li J, Zhou Y, Sun D, Huang Y. Cancer Research. 2021,81(8):1965-76. Engineering supramolecular organizing centers for optogenetic control of innate immune responses. Tan P, He L, and Zhou Y#. Advanced Biology. 2021,5(5):e2000147. STIM1 deficiency in intestinal epithelium attenuates colonic inflammation by reducing ER stress of goblet cells. Liang X, Xie J, Liu H, Zhao R, Zhang W, Wang H, Pan H, Zhou Y, and Han W. Cellular and Molecular Gastroenterology and Hepatology. 2022,14(1):193-217.
Structural determinants for light-dependent membrane binding of a photoswitchable polybasic domain. Ling L, He L, Wu B, Yu C, Zhao H, Zhou Y#, Wang J# and Zhu L#. ACS Synthetic Biology. 2021,10(3):542-51.
Design of smart antibody mimetics with photosensitive switches. He L, Wang T, Huang Y, and Zhou Y#. Advanced Biology. 2021,5(5):e2000541. Featured as a back Cover Article; Highlighted by preLights: “Shining light on immunology’s dark corners” Dimming the donor to brighten up FRET-based biosensors. Jing J, Zhou Y, and Wang Y. Cell Calcium. 2021,99:102474.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Klionsky DJ. et al. (The autophagy research community) Autophagy. 2021,17(1):1-382. Optogenetic control of calcium influx in mammalian cells. Lee, YT, Chen R, Zhou Y#, and He L#. Methods in Enzymology. 2021,654:255-70.
Store-operated ORAI calcium channels. Nguyen NT, Zhou Y#. Edited by Joseph Jez. Encyclopedia of Biological Chemistry 3rd Edition. Elsevier Inc. 2021.
Circularly permuted LOV2 as a modular domain for optogenetic engineering. He L, Tan P, Zhu L, Huang L, Nguyen NT, Huang Y, Han G, Wang J, Zhou Y#. Nature Chemical Biology. 2021,17(8):915-23. *First report of LOV2 circular permutants for design of light-switchable CAR T-cells; *Featured in Nature Portfolio – Chemical Tools Collection; Highlighted as “Paper of the Month” by OptoBase; *Highlighted by Optics and Photonics News:”Modular blue light-sensitive photoswitch developed for optogenetic engineering”; *Recommended by Faculty Opinion (9.3/10; top 0.5% in Chemical Biology): 10.3410/f.740063208.793587708 Expression of chimeric antigen receptor therapy targets detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity. Jing Y, Liu Y, Li Q, Ye Y, Diao L, Huang Y, Zhou Y, Green MR, Mills GB, and Han L. Cancer Cell. 2021,39(12):1558-9.
Engineering of a bona fide light-operated calcium channel. He L, Wang L, Zeng H, Tan P, Ma G, Zheng S, Li Y, Sun L, Dou F, Huang Y, Wang Y, and Zhou Y#. Nature Communications. 2021,12:164. *Highlighted in Commentary by Cell Calcium: “Blue light opens the ORAI1 LOC(K)”; *Featured in Nature Communications Editor’s Highlights “Biotechnology and methods”
Optogenetic control of non-apoptotic cell death. He L, Huang Z, Huang K, Chen R, Nguyen NT, Wang R, Cai X, Huang Z, Siwko S, Walker JR, Han G#, Zhou Y#, and Jing J#. Advanced Science. 2021,2100424. (IF: 16.806) * Highlighted as a Cover Article; Collaboration with Promega for first demonstration of NanoLuc based wireless optogenetics Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility. Ma T, Huang Z, Xie X, Zhuang X, Childs M, Gangal H, Wang X, Smith LN, Smith R, Zhou Y, and Wang J. Journal of Clinical Investigation. 2021,e154969. Caffeine-operated synthetic modules for chemogenetic control of protein activities by life style. Wang T, He L, Jing J, Lan TH, Hong T, Wang F, Huang Y, Ma G, and Zhou Y#. Advanced Science. 2021,8(3):2002148. *Highlighted as a Cover Article; Featured by Vital Record: “Using caffeine to ward off disease” *Interview with KBTX News 3 Channel: “Researchers at Texas A&M using caffeine to help fight off viruses like COVID-19”
TET2 inactivation enhances the anti-tumor activity of tumor-infiltrating lymphocytes. Lee MJ, Li J, Fang S, Zhang J, Vo AT, Han W, Zeng H, Isgandarova S, Martinze-Moczygemba M, Li J, Zhou Y, Sun D, Huang Y. Cancer Research. 2021,81(8):1965-76. Engineering supramolecular organizing centers for optogenetic control of innate immune responses. Tan P, He L, and Zhou Y#. Advanced Biology. 2021,5(5):e2000147. STIM1 deficiency in intestinal epithelium attenuates colonic inflammation by reducing ER stress of goblet cells. Liang X, Xie J, Liu H, Zhao R, Zhang W, Wang H, Pan H, Zhou Y, and Han W. Cellular and Molecular Gastroenterology and Hepatology. 2022,14(1):193-217.
Structural determinants for light-dependent membrane binding of a photoswitchable polybasic domain. Ling L, He L, Wu B, Yu C, Zhao H, Zhou Y#, Wang J# and Zhu L#. ACS Synthetic Biology. 2021,10(3):542-51.
Design of smart antibody mimetics with photosensitive switches. He L, Wang T, Huang Y, and Zhou Y#. Advanced Biology. 2021,5(5):e2000541. Featured as a back Cover Article; Highlighted by preLights: “Shining light on immunology’s dark corners” Dimming the donor to brighten up FRET-based biosensors. Jing J, Zhou Y, and Wang Y. Cell Calcium. 2021,99:102474.
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Klionsky DJ. et al. (The autophagy research community) Autophagy. 2021,17(1):1-382. Optogenetic control of calcium influx in mammalian cells. Lee, YT, Chen R, Zhou Y#, and He L#. Methods in Enzymology. 2021,654:255-70.
Store-operated ORAI calcium channels. Nguyen NT, Zhou Y#. Edited by Joseph Jez. Encyclopedia of Biological Chemistry 3rd Edition. Elsevier Inc. 2021.